Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses.

ABSTRACT: Dengue virus is a mosquito borne Flavivirus and the most prevalent arbovirus in tropical and subtropical regions around the world. The incidence of dengue has increased drastically over the last few years at an alarming rate. The clinical manifestation of dengue ranges from asymptomatic infection to severe dengue. Even though the viral kinetics of dengue infection is lacking, innate immune response and humoral immune response are thought to play a major role in controlling the virus count. Here, we developed a computer simulation mathematical model including both innate and adaptive immune responses to study the within-host dynamics of dengue virus infection. A sensitivity analysis was carried out to identify key parameters that would contribute towards severe dengue. A detailed stability

SUBMITTER: Perera SD 

PROVIDER: S-EPMC5925133 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature