Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation.

ABSTRACT:

Aim

We conducted a joint metabolomic-epigenomic study to identify patterns of epigenetic associations with smoking-related metabolites.

Patients & methods

We performed an untargeted metabolome-wide association study of smoking and epigenome-wide association studies of smoking-related metabolites among 180 male twins. We examined the patterns of epigenetic association linked to smoking-related metabolites using hierarchical clustering.

Results

Among 12 annotated smoking-related metabolites identified from a metabolome-wide association study, we observed significant hypomethylation associated with increased level of N-acetylpyrrolidine, cotinine, 5-hydroxycotinine and nicotine and hypermethylation associated with increased level of 8-oxoguanine. Hierarchical clustering

SUBMITTER: Huang Y 

PROVIDER: S-EPMC5925442 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature