Ontology highlight
ABSTRACT: Research in context
Alternative (M2-type) macrophage activation through IL-4R? promotes liver inflammation and fibrosis progression but speeds up fibrosis reversal. This demonstrates context dependent, opposing roles of M2-type macrophages. During reversal IL-4R? induces fibrolytic MMPs, especially MMP-12, through STAT6. Liver-specific antisense oligonucleotides efficiently block IL-4R? expression and attenuate fibrosis progression.
SUBMITTER: Weng SY
PROVIDER: S-EPMC5925448 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
EBioMedicine 20180217
Chronic hepatitis leads to liver fibrosis and cirrhosis. Cirrhosis is a major cause of worldwide morbidity and mortality. Macrophages play a key role in fibrosis progression and reversal. However, the signals that determine fibrogenic vs fibrolytic macrophage function remain ill defined. We studied the role of interleukin-4 receptor α (IL-4Rα), a potential central switch of macrophage polarization, in liver fibrosis progression and reversal. We demonstrate that inflammatory monocyte infiltration ...[more]