Pathophysiological Characteristics Associated With Epileptogenesis in Human Hippocampal Sclerosis.

ABSTRACT: Mesial temporal lobe epilepsy (MTLE) is the most frequent focal epileptic syndrome in adults, and the majority of seizures originate primarily from the hippocampus. The resected hippocampal tissue often shows severe neuronal loss, a condition referred to as hippocampal sclerosis (HS). In order to understand hippocampal epileptogenesis in MTLE, it seems important to clarify any discrepancies between the clinical and pathological features of affected patients. Here we investigated epileptiform activities ex vivo using living hippocampal tissue taken from patients with MTLE. Flavoprotein fluorescence imaging and local field potential recordings revealed that epileptiform activities developed from the subiculum. Moreover, physiological and morphological experiments revealed possible impairment

SUBMITTER: Kitaura H 

PROVIDER: S-EPMC5925580 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature