Aspartyl proteases in <i>Candida glabrata</i> are required for suppression of the host innate immune response.

ABSTRACT: A family of 11 cell surface-associated aspartyl proteases (CgYps1-11), also referred as yapsins, is a key virulence factor in the pathogenic yeast Candida glabrata However, the mechanism by which CgYapsins modulate immune response and facilitate survival in the mammalian host remains to be identified. Here, using RNA-Seq analysis, we report that genes involved in cell wall metabolism are differentially regulated in the Cgyps1-11Δ mutant. Consistently, the mutant contained lower β-glucan and mannan levels and exhibited increased chitin content in the cell wall. As cell wall components are known to regulate the innate immune response, we next determined the macrophage transcriptional response to C. glabrata infection and observed differential expression of genes implicat

SUBMITTER: Rasheed M 

PROVIDER: S-EPMC5925793 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature