Inhibition of strigolactone receptors by N-phenylanthranilic acid derivatives: Structural and functional insights.

ABSTRACT: The strigolactone (SL) family of plant hormones regulates a broad range of physiological processes affecting plant growth and development and also plays essential roles in controlling interactions with parasitic weeds and symbiotic fungi. Recent progress elucidating details of SL biosynthesis, signaling, and transport offers many opportunities for discovering new plant-growth regulators via chemical interference. Here, using high-throughput screening and downstream biochemical assays, we identified N-phenylanthranilic acid derivatives as potent inhibitors of the SL receptors from petunia (DAD2), rice (OsD14), and Arabidopsis (AtD14). Crystal structures of DAD2 and OsD14 in complex with inhibitors further provided detailed insights into the inhibition mechanism, and in sili

SUBMITTER: Hamiaux C 

PROVIDER: S-EPMC5925799 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature