Identification of serum proteins AHSG, FGA and APOA-I as diagnostic biomarkers for gastric cancer.

ABSTRACT:

Background

The development of clinically accessible biomarkers is critical for the early diagnosis of gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a serum peptide profile but also provide a new approach to identify potentially diagnostic and prognostic biomarkers for cancer patients.

Methods

In this study, we aim to identify potentially discriminating serum biomarkers for GC. In the discovery cohort, we screened potential biomarkers using magnetic-bead-based purification and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in 64 samples from 32 GC patients that were taken both pre- and post-operatively and 30 healthy volunteers that served as controls. In the validation cohort, the expr

SUBMITTER: Shi F 

PROVIDER: S-EPMC5925839 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature