A double-blind, randomized comparative study to investigate the morphine to hydromorphone conversion ratio in Japanese cancer patients.

ABSTRACT:

Objective

To confirm the morphine to hydromorphone conversion ratio for hydromorphone (DS-7113b) immediate-release tablets in cancer patients who achieved pain control with oral morphine.

Methods

This was a multicenter, active-controlled, randomized, double-blind, parallel-group, comparative study (July 2013 to December 2014) at 39 Japanese sites. Seventy-one patients (aged >20 years) who had achieved pain control with morphine 60 mg/day and 90 mg/day were randomly allocated 1:1 to hydromorphone immediate-release tablets at a dose converted at a hydromorphone:morphine ratio of 1:5 or 1:8, respectively, and treated for up to 5 days. The efficacy was evaluated as the pain control ratio.

Results

The pain control ratio in the full analysis set was 83.3% (25/30) in the con

SUBMITTER: Inoue S 

PROVIDER: S-EPMC5926545 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature