Collagen overlays can inhibit leptin and adiponectin secretion but not lipid accumulation in adipocytes.

ABSTRACT:

Background

White adipose tissue (WAT) is essential for energy storage as well as being an active endocrine organ. The secretion of adipokines by adipocytes can affect whole body metabolism, appetite, and contribute to overall health. WAT is comprised of lipid-laden mature adipocytes, as well as immune cells, endothelial cells, pre-adipocytes, and adipose-derived stem cells. In addition, the presence of extracellular matrix (ECM) proteins in WAT can actively influence adipocyte differentiation, growth, and function. Type I collagen is an abundant fibrous ECM protein in WAT that is secreted by developing adipocytes. However, the extent and overall effect of Type I collagen on adipokine secretion in mature adipocytes when added exogenously has not been established.

Methods

We c

SUBMITTER: Christian SL 

PROVIDER: S-EPMC5926549 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature