Serum Proteomics in African American Female Patients With Irritable Bowel Syndrome: An Exploratory Study.

ABSTRACT:

Background

Sex and subtype differences within patients with irritable bowel syndrome (IBS) complicate the understanding of disorder pathogenesis and hinder the design of efficacious, therapeutic interventions.

Objectives

The aims of this study were to harness the power of shotgun proteomic analysis, identify circulating proteins that differentiate African American female patients with IBS from healthy controls (HC), and gain biological insight on symptomatology.

Methods

Serum proteome analysis was performed upon a cohort of overweight, African American female participants with constipation predominant IBS symptoms (n = 5) and HC (n = 5), matched on age, sex, years of education, body mass index, and 11 physiological markers. Tandem mass tags for multiplexed proteomic a

SUBMITTER: Weaver KR 

PROVIDER: S-EPMC5926805 | biostudies-literature | 2018 May/Jun

REPOSITORIES: biostudies-literature