Elevated circulating miR-182 acts as a diagnostic biomarker for early colorectal cancer.

ABSTRACT:

Purpose

Globally, colorectal cancer (CRC) is one of the most common cancers with high mortality. Although CRC patients in stages I-II are curable after surgical resection, due to the lack of sensitive and specific biomarkers, many patients are in the advanced stages when diagnosed. This study aimed to investigate whether circulating miRNAs in plasma could act as biomarkers for early CRC diagnosis.

Patients and methods

All healthy subjects and patients were from Nanjing First Hospital. We first selected 2 differential miRNAs by integrated analysis of 4 Gene Expression Omnibus (GEO) data sets and The Cancer Genome Atlas (TCGA) database. Next, the expression of these 2 miRNAs in tissue and plasma samples were examined through quantitative real-time polymerase chain reaction. Tr

SUBMITTER: Liu X 

PROVIDER: S-EPMC5927061 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature