Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles.

ABSTRACT:

Objectives

Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer's disease (AD) and episodic memory (EM) decline. Memory resilience occurs when genetically at-risk adults perform at high and sustained levels. We investigated whether (a) memory resilience to AD genetic risk is predicted by biological and other risk markers and (b) the prediction profiles vary by sex and AD risk variant.

Method

Using a longitudinal sample of nondemented adults (n = 642, aged 53-95) we focused on memory resilience (over 9 years) to 2 AD risk variants (APOE, CLU). Growth mixture models classified resilience. Random forest analysis, stratified by sex, tested the predictive importance of 22 nongenetic risk factors from 5 domains (n = 24-112).

Results

For bo

SUBMITTER: McDermott KL 

PROVIDER: S-EPMC5927155 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature