Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Growth differentiation factor 11 (GDF11) is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decreased circulating GDF11 in the pathophysiology of COPD remains unknown. The aim of this study is to investigate the association between the plasma GDF11 levels and various clinical parameters in patients with COPD.

Patients and methods

Eighteen ex-smokers as control subjects and 70 COPD patients participated in the current study. We measured the levels of plasma GDF11 using immunoblotting, lung function, physical activity using a triaxial accelerometer, quadriceps strength, exercise

SUBMITTER: Tanaka R 

PROVIDER: S-EPMC5927187 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature