Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.

ABSTRACT: Voltage-gated Na⁺ channels (Na_v ) modulate neuronal excitability, but the roles of the various Na_v subtypes in specific neuronal functions such as synaptic transmission are unclear. We investigated expression of the three major brain Na_v subtypes (Na_v 1.1, Na_v 1.2, Na_v 1.6) in area CA1 and dentate gyrus of rat hippocampus. Using light and electron microscopy, we found labeling for all three Na_v subtypes on dendrites, dendritic spines, and axon terminals, but the proportion of pre- and post-synaptic labeling for each subtype varied within and between subregions of CA1 and dentate gyrus. In the central hilus (CH) of the dentate gyrus, Na_v 1.1 immunoreactivity was selectively expressed in presyn

SUBMITTER: Johnson KW 

PROVIDER: S-EPMC5927368 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature