AhR activation increases IL-2 production by alloreactive CD4⁺ T cells initiating the differentiation of mucosal-homing Tim3⁺ Lag3⁺ Tr1 cells.

ABSTRACT: Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes the development of regulatory T (Treg) cells. Although AhR-induced Foxp3⁺ Treg cells have been well studied, much less is known about the development and fate of AhR-induced Type 1 Treg (AhR-Tr1) cells. In the current study, we identified the unique transcriptional and functional changes in murine CD4⁺ T cells that accompany the differentiation of AhR-Tr1 cells during the CD4⁺ T-cell-dependent phase of an allospecific cytotoxic T lymphocyte (allo-CTL) response. AhR activation increased the expression of genes involved in T-cell activation, immune regulation and chemotaxis, as well as a global downregulation of genes involved in cell cycling.  Increased IL-2 production wa

SUBMITTER: Ehrlich AK 

PROVIDER: S-EPMC5927372 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature