Temporal evolution of HIV sero-discordancy patterns among stable couples in sub-Saharan Africa.

ABSTRACT:

Introduction

Objective was to examine the temporal variation of HIV sero-discordancy in select representative countries (Kenya, Lesotho, Mali, Niger, Tanzania, and Zimbabwe) in sub-Saharan Africa at different HIV epidemic scales. A sero-discordant couple is defined as a stable couple (SC) in which one partner is HIV-positive while the other is HIV-negative.

Methods

A deterministic compartmental mathematical model was constructed to describe HIV transmission dynamics. The model was pair-based, that is explicitly modeling formation of SCs and infection dynamics in both SCs and in single individuals. The model accommodated for different forms of infection statuses in SCs. Using population-based nationally-representative epidemiologic and demographic input data, historical (1980

SUBMITTER: Awad SF 

PROVIDER: S-EPMC5927442 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature