Myeloid-derived macrophages and secreted HSP90α induce pancreatic ductal adenocarcinoma development.

ABSTRACT: We detected a significant elevation of serum HSP90α levels in pancreatitis patients and even more in pancreatic ductal adenocarcinoma (PDAC) patients. However, there was no significant difference in the serum HSP90α levels between patients with early-stage and late-stage PDAC. To study whether elevation of serum HSP90α levels occurred early during PDAC development, we used LSL-KrasG12D/Pdx1-Cre transgenic mice as a studying model. Elevated serum HSP90α levels were detected before PDAC formation and an extracellular HSP90α (eHSP90α) inhibitor effectively prevented PDAC development. Both serum HSP90α level and pancreatic lesion were suppressed when the mice were administered a CD11b-antagonizing antibody, suggesting that CD11b⁺-myeloid cells were associated with eHSP90α levels and

SUBMITTER: Chen CC 

PROVIDER: S-EPMC5927518 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature