Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.

ABSTRACT: The 20 members of the Rho GTPase family are key regulators of a wide-variety of biological activities. In response to activation, they signal via downstream effector proteins to induce dynamic alterations in the organization of the actomyosin cytoskeleton. In this review, post-translational modifications, mechanisms of dysregulation identified in human pathological conditions, and the ways that Rho GTPases might be targeted for chemotherapy will be discussed.

SUBMITTER: Olson MF 

PROVIDER: S-EPMC5927519 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature