TNFa and IL-2 armed adenoviruses enable complete responses by anti-PD-1 checkpoint blockade.

ABSTRACT: Releasing the patient's immune system against their own malignancy by the use of checkpoint inhibitors is delivering promising results. However, only a subset of patients currently benefit from them. One major limitation of these therapies relates to the inability of T cells to detect or penetrate into the tumor resulting in unresponsiveness to checkpoint inhibition. Virotherapy is an attractive tool for enabling checkpoint inhibitors as viruses are naturally recognized by innate defense elements which draws the attention of the immune system. Besides their intrinsic immune stimulating properties, the adenoviruses used here are armed to express tumor necrosis factor alpha (TNFa) and interleukin-2 (IL-2). These cytokines result in immunological danger signaling and multiple appealing T-cell

SUBMITTER: Cervera-Carrascon V 

PROVIDER: S-EPMC5927535 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature