A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients.

ABSTRACT: Adult T-cell leukemia (ATL) is an aggressive, chemotherapy-resistant CD4⁺CD25⁺ leukemia caused by HTLV-1 infection, which usually develops in a minority of patients several decades after infection. IFN + AZT combination therapy has shown clinical benefit in ATL, although its mechanism of action remains unclear. We have previously shown that an IFN-responsive FAS promoter polymorphism in a STAT1 binding site (rs1800682) is associated to ATL susceptibility and survival. Recently, CD4 T stem cell memory (T_SCM) Fas^hi cells have been identified as the hierarchical cellular apex of ATL, but a possible link between FAS, apoptosis, proliferation and IFN response in ATL has not been studied. In this study, we found significant ex vivo antiprolifera

SUBMITTER: Khouri R 

PROVIDER: S-EPMC5927537 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature