Elongated Plant Virus-Based Nanoparticles for Enhanced Delivery of Thrombolytic Therapies.

ABSTRACT: Thrombotic cardiovascular disease, including acute myocardial infarction, ischemic stroke, and venous thromboembolic disease, is the leading cause of morbidity and mortality worldwide. While reperfusion therapy with thrombolytic agents reduces mortality from acute myocardial infarction and disability from stroke, thrombolysis is generally less effective than mechanical reperfusion and is associated with fatal intracerebral hemorrhage in up to 2-5% of patients. To address these limitations, we propose the tobacco mosaic virus (TMV)-based platform technology for targeted delivery of thrombolytic therapies. TMV is a plant virus-based nanoparticle with a high aspect ratio shape measuring 300 × 18 nm. These soft matter nanorods have favorable flow and margination properties allowing the targeti

SUBMITTER: Pitek AS 

PROVIDER: S-EPMC5927583 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature