Enantioselective γ-C(sp³)-H Activation of Alkyl Amines via Pd(II)/Pd(0) Catalysis.

ABSTRACT: Pd(II)-catalyzed enantioselective γ-C(sp³)-H cross-coupling of alkyl amines via desymmetrization and kinetic resolution has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands (APAO). A diverse range of aryl- and vinyl-boron reagents can be used as coupling partners. The chiral γ-arylated alkylamine products are further transformed into chiral 2-substituted 1,2,3,4-tetra-hydroquinolines and spiro-pyrrolidines as important structural motifs in natural products and biologically active molecules.

SUBMITTER: Shao Q 

PROVIDER: S-EPMC5927623 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature