Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics.

ABSTRACT: To understand the brain, molecular details need to be overlaid onto neural wiring diagrams so that synaptic mode, neuromodulation and critical signaling operations can be considered. Single-cell transcriptomics provide a unique opportunity to collect this information. Here we present an initial analysis of thousands of individual cells from Drosophila midbrain, that were acquired using Drop-Seq. A number of approaches permitted the assignment of transcriptional profiles to several major brain regions and cell-types. Expression of biosynthetic enzymes and reuptake mechanisms allows all the neurons to be typed according to the neurotransmitter or neuromodulator that they produce and presumably release. Some neuropeptides are preferentially co-expressed in neurons using a particular fa

SUBMITTER: Croset V 

PROVIDER: S-EPMC5927767 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature