RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice.

ABSTRACT: Sickle cell disease patients are at increased risk of developing a chronic kidney disease. Endothelial dysfunction and inflammation associated with hemolysis lead to vasculopathy and contribute to the development of renal disease. Here we used a Townes sickle cell disease mouse model to examine renal endothelial injury. Renal disease in Townes mice was associated with glomerular hypertrophy, capillary dilation and congestion, and significant endothelial injury. We also detected substantial renal macrophage infiltration, and accumulation of macrophage stimulating protein 1 in glomerular capillary. Treatment of human cultured macrophages with hemin or red blood cell lysates significantly increased expression of macrophage membrane-associated protease that might cleave and activate circulatin

SUBMITTER: Khaibullina A 

PROVIDER: S-EPMC5927980 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature