G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old.

ABSTRACT: Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China. Community-dwelling Chinese residents aged 90 years or older were included in this study. Frailty was determined using the FRAIL scale as proposed by the International Association of Nutrition and Aging. On the FRAIL scale, frailty was defined by a score of ≥3. G-39

SUBMITTER: Hao Q 

PROVIDER: S-EPMC5928057 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature