Regulation of DNA damage repair and lipid uptake by CX₃CR1 in epithelial ovarian carcinoma.

ABSTRACT: Failure of currently used cytotoxic chemotherapy is one of the main reasons behind high mortality from metastatic high grade serous ovarian carcinoma. We found that high expression of a receptor for fractalkine (CX₃CR1) significantly correlated with shorter survival of patients with serous ovarian carcinoma treated with cytotoxic DNA damage chemotherapies, and reduction of CX₃CR1 expression resulted in sensitization to several DNA damaging modalities, including x-ray radiation and cisplatin. Here, we show that CX₃CR1 plays a role in double-strand DNA break response and repair by regulating expression of RAD50 by a MYC-dependent mechanism. We demonstrate that downregulation of CX₃CR1 alone and in a combination with irradiation affects peritoneal m

SUBMITTER: Xie J 

PROVIDER: S-EPMC5928120 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature