High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages.

ABSTRACT: Immune responses to parasitic pathogens are affected by the host physiological condition. High-density lipoprotein (HDL) and low-density lipoprotein (LDL) are transporters of lipids between the liver and peripheral tissues, and modulate pro-inflammatory immune responses. Pathogenic mycobacteria are parasitic intracellular bacteria that can survive within macrophages for a long period. Macrophage function is thus key for host defense against mycobacteria. These basic facts suggest possible effects of HDL and LDL on mycobacterial diseases, which have not been elucidated so far. In this study, we found that HDL and not LDL enhanced mycobacterial infections in human macrophages. Nevertheless, we observed that HDL remarkably suppressed production of tumor necrosis factor alpha (TNF-α) upon myco

SUBMITTER: Inoue M 

PROVIDER: S-EPMC5928146 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature