Integrated Quantitative Transcriptome Maps of Human Trisomy 21 Tissues and Cells.

ABSTRACT: Down syndrome (DS) is due to the presence of an extra full or partial chromosome 21 (Hsa21). The identification of genes contributing to DS pathogenesis could be the key to any rational therapy of the associated intellectual disability. We aim at generating quantitative transcriptome maps in DS integrating all gene expression profile datasets available for any cell type or tissue, to obtain a complete model of the transcriptome in terms of both expression values for each gene and segmental trend of gene expression along each chromosome. We used the TRAM (Transcriptome Mapper) software for this meta-analysis, comparing transcript expression levels and profiles between DS and normal brain, lymphoblastoid cell lines, blood cells, fibroblasts, thymus and induced pluripotent stem cells, respect

SUBMITTER: Pelleri MC 

PROVIDER: S-EPMC5928158 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature