Pathological Margin Clearance and Survival After Pancreaticoduodenectomy in a US and European Pancreatic Center.

ABSTRACT:

Background

The optimal definition of a margin-negative resection and its exact prognostic significance on survival in resected pancreatic adenocarcinoma remains unknown. This study was designed to assess the relationship between pathological margin clearance, margin type, and survival.

Methods

Patients who underwent pancreaticoduodenectomy with curative intent at two academic institutions, in Amsterdam, the Netherlands, and Boston, Massachusetts, between 2000 and 2014 were retrospectively evaluated. Overall survival, recurrence rates, and progression-free survival (PFS) were assessed by Kaplan-Meier estimates and multivariate Cox proportional hazards analysis, according to pathological margin clearance and type of margin involved.

Results

Of 531 patients identified, t

SUBMITTER: van Roessel S 

PROVIDER: S-EPMC5928169 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature