Impact of intranasal oxytocin on interoceptive accuracy in alcohol users: an attentional mechanism?

ABSTRACT: Interoception, i.e. the perception and appraisal of internal bodily signals, is related to the phenomenon of craving, and is reportedly disrupted in alcohol use disorders. The hormone oxytocin influences afferent transmission of bodily signals and, through its potential modulation of craving, is proposed as a possible treatment for alcohol use disorders. However, oxytocin's impact on interoception in alcohol users remains unknown. Healthy alcohol users (n = 32) attended two laboratory sessions to perform tests of interoceptive ability (heartbeat tracking: attending to internal signals and, heartbeat discrimination: integrating internal and external signals) after intranasal administration of oxytocin or placebo. Effects of interoceptive accuracy, oxytocin administration and alcohol intake,

SUBMITTER: Betka S 

PROVIDER: S-EPMC5928407 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature