LPA kringle IV type 2 is associated with type 2 diabetes in a Chinese population with very high cardiovascular risk.

ABSTRACT: The connection between lipoprotein (a) [Lp(a)] levels and the risks of cardiovascular disease and diabetes remains poorly understood. Lp(a) is encoded by the LPA gene, and evidence suggests that the kringle IV type 2 (KIV-2) variant is particularly important to Lp(a) isoform size. A large isoform size, represented as a high number of KIV-2 repeats in LPA, is associated with low serum Lp(a) concentrations and an increased risk of type 2 diabetes. We investigated the associations among Lp(a) concentrations, LPA KIV-2 repeats, and type 2 diabetes in a Chinese population of 1,863 consecutive patients with very high cardiovascular risk, as identified by coronary angiography. Individuals with Lp(a) levels in the top tertile [67.86 (35.34-318.50) mg/dl] had a lower risk of di

SUBMITTER: Mu-Han-Ha-Li 迪丽达尔 木汗哈力 DL 

PROVIDER: S-EPMC5928429 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature