AIBP protects against metabolic abnormalities and atherosclerosis.

ABSTRACT: Apolipoprotein A-I binding protein (AIBP) has been shown to augment cholesterol efflux from endothelial cells and macrophages. In zebrafish and mice, AIBP-mediated regulation of cholesterol levels in the plasma membrane of endothelial cells controls angiogenesis. The goal of this work was to evaluate metabolic changes and atherosclerosis in AIBP loss-of-function and gain-of-function animal studies. Here, we show that Apoa1bp^-/-Ldlr^-/- mice fed a high-cholesterol, high-fat diet had exacerbated weight gain, liver steatosis, glucose intolerance, hypercholesterolemia, hypertriglyceridemia, and larger atherosclerotic lesions compared with Ldlr^-/- mice. Feeding Apoa1bp^-/-Ldlr^-/- mice a high-cholesterol, normal-fat diet d

SUBMITTER: Schneider DA 

PROVIDER: S-EPMC5928435 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature