Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors.

ABSTRACT:

Background

Several candidate genes have been identified in relation to lipid metabolism, and among these, lipoprotein lipase (LPL) and apolipoprotein E (APOE) gene polymorphisms are major sources of genetically determined variation in lipid concentrations. This study investigated the association of two single nucleotide polymorphisms (SNPs) at LPL, seven tagging SNPs at the APOE gene, and a common APOE haplotype (two SNPs) with blood lipids, and examined the interaction of these SNPs with dietary factors.

Methods

The population studied for this investigation included 660 individuals from the Prevention of Cancer by Intervention with Selenium (PRECISE) study who supplied baseline data. The findings of the PRECISE study were further replicated using 1238 individuals from the C

SUBMITTER: Shatwan IM 

PROVIDER: S-EPMC5928585 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature