Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.

ABSTRACT:

Background

Gastric cancer is currently the fourth leading cause of cancer-related death worldwide. Gastric cancer is often diagnosed at advanced stages and the outcome of the treatment is often poor. Therefore, identifying new therapeutic targets for this cancer is urgently needed. Integrin alpha 2 (ITGA2) subunit and the beta 1 subunit form a heterodimer for a transmembrane receptor for extracellular matrix, is an important molecule involved in tumor cell proliferation, survival and migration. Integrin α2β1 is over-expressed on a variety of cancer cells, but is low or absent in most normal organs and resting endothelial cells.

Results

In this report, we assessed the ITGA2 as the potential therapeutic target with the bioinformatics tools from the TCGA dataset in which compos

SUBMITTER: Chuang YC 

PROVIDER: S-EPMC5928594 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature