Identification of potential genes and miRNAs associated with sepsis based on microarray analysis.

ABSTRACT: Sepsis is a type of systemic inflammatory response syndrome caused by infection. The present study aimed to examine key genes and microRNAs (miRNAs) involved in the pathogenesis of sepsis. The GSE13205 microarray dataset, downloaded from the Gene Expression Omnibus was analyzed using bioinformatics tools, and included muscle biopsy specimens of 13 patients with sepsis and eight healthy controls. The differentially expressed genes (DEGs) in samples from patients with sepsis were identified using the Linear Models for Microarray package in R language. Using the Database for Annotation, Visualization and Integration Discovery tool, functional and pathway enrichment analyses were performed to examine the potential functions of the DEGs. The protein‑protein interaction (PPI) network was constru

SUBMITTER: Li Y 

PROVIDER: S-EPMC5928603 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature