Identification of the key genes associated with neuropathic pain.

ABSTRACT: Neuropathic pain is a chronic pain state associated with multiple etiologies that results in considerable social and economic burden. The identification of key genes associated with neuropathic pain is important for the development of novel therapies. Therefore, the present study downloaded the gene expression profile GSE15041 from the Gene Expression Omnibus database. The unverified gene chip was removed and the microarray data was normalized following quality control. The limma package in R was used to screen the differentially expressed genes (DEGs), followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Furthermore, a protein‑protein interaction (PPI) network based on the identified DEGs was constructed to select hub proteins, and reve

SUBMITTER: Liu H 

PROVIDER: S-EPMC5928612 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature