Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma.

ABSTRACT: We generated a comprehensive atlas of the immunologic cellular networks within human malignant pleural mesothelioma (MPM) using mass cytometry. Data-driven analyses of these high-resolution single-cell data identified 2 distinct immunologic subtypes of MPM with vastly different cellular composition, activation states, and immunologic function; mass spectrometry demonstrated differential abundance of MHC-I and -II neopeptides directly identified between these subtypes. The clinical relevance of this immunologic subtyping was investigated with a discriminatory molecular signature derived through comparison of the proteomes and transcriptomes of these 2 immunologic MPM subtypes. This molecular signature, representative of a favorable intratumoral cell network, was independently associated wit

SUBMITTER: Lee HS 

PROVIDER: S-EPMC5928857 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature