Paper-based electrochemiluminescence sensor for highly sensitive detection of amyloid-β oligomerization: Toward potential diagnosis of Alzheimer's disease.

ABSTRACT: Development of a rapid and sensitive method for Aβ(1-42) aggregation detection is of great importance to overcome the limitations of conventional techniques. In this study, we developed a label-free paper-based electrochemiluminescence sensor for amyloid-β aggregation detection toward potential diagnosis of Alzheimer's disease (AD). The paper-based chip used in the system serves as a low-cost and disposable detection method. In this detection platform, the bonding of [Ru(phen)₂dppz]²⁺ to Aβ(1-42) aggregates results in enhanced electrochemiluminescence due to the change in the polarity of the microenvironment when [Ru(phen)₂dppz]²⁺ intercalated into the β-sheets during oligomerization. The oligomerization process of Aβ(1-42) can be monitored in re

SUBMITTER: Liu H 

PROVIDER: S-EPMC5928890 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature