The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults.

ABSTRACT: An important characteristic of spontaneous brain activity is the anticorrelation between the core default network (cDN) and the dorsal attention network (DAN) and the salience network (SN). This anticorrelation may constitute a key aspect of functional anatomy and is implicated in several brain disorders. We used dynamic causal modeling to assess the hypothesis that a causal hierarchy underlies this anticorrelation structure, using resting-state fMRI of healthy adolescent and young adults (N = 404). Our analysis revealed an asymmetric effective connectivity, such that the regions in the SN and DAN exerted an inhibitory influence on the cDN regions; whereas the cDN exerted an excitatory influence on the SN and DAN regions. The relative strength of efferent versus afferent connections places

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5929108 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature