Clinical, Bacteriologic, and Geographic Stratification of Melioidosis Emerges from the Sri Lankan National Surveillance Program.

ABSTRACT: Melioidosis, a potentially fatal tropical infection, is said to be underdiagnosed in low-income countries. An increase in melioidosis cases in Sri Lanka allowed us to analyze the relationship among clinical outcome, bacteriology, epidemiology, and geography in the first 108 laboratory-confirmed cases of melioidosis from a nationwide surveillance program. The additional 76 cases of laboratory-confirmed melioidosis confirmed further associations between Burkholderia pseudomallei multilocus sequence typing (MLST) and infection phenotype; ST1137/unifocal bacteremic infection (χ² = 3.86, P < 0.05), ST1136/multifocal infection without bacteremia (χ² = 15.8, P < 0.001), and ST1132/unifocal nonbacteremic infection (χ² = 6.34, P = 0.02).

SUBMITTER: Sathkumara HD 

PROVIDER: S-EPMC5929190 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature