Bladder Cancer Genetic Susceptibility. A Systematic Review.

ABSTRACT:

Background

The variant/gene candidate approach to explore bladder cancer (BC) genetic susceptibility has been applied in many studies with significant findings reported. However, results are not always conclusive due to the lack of replication by subsequent studies.

Objectives

To identify all epidemiological investigations on the genetic associations with BC risk, to quantify the likely magnitude of the associations by applying metaanalysis methodology and to assess whether there is a potential for publication/reporting bias.

Methods

To address our aims, we have catalogued all genetic association studies published in the field of BC risk since 2000. Furthermore, we metaanalysed all polymorphisms with data available from at least three independent case-control studies

SUBMITTER: de Maturana EL 

PROVIDER: S-EPMC5929300 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature