FusionHub: A unified web platform for annotation and visualization of gene fusion events in human cancer.

ABSTRACT: Gene fusion is a chromosomal rearrangement event which plays a significant role in cancer due to the oncogenic potential of the chimeric protein generated through fusions. At present many databases are available in public domain which provides detailed information about known gene fusion events and their functional role. Existing gene fusion detection tools, based on analysis of transcriptomics data usually report a large number of fusion genes as potential candidates, which could be either known or novel or false positives. Manual annotation of these putative genes is indeed time-consuming. We have developed a web platform FusionHub, which acts as integrated search engine interfacing various fusion gene databases and simplifies large scale annotation of fusion genes in a seamless way. In

SUBMITTER: Panigrahi P 

PROVIDER: S-EPMC5929557 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature