Association of CDKAL1 Polymorphisms with Early-Onset Atopic Dermatitis in Koreans.

ABSTRACT:

Background

Atopic dermatitis (AD) has increased in frequency to rates as high as 20% for children in developed countries. AD is one of the most common childhood diseases and has a complex etiology involving genetic and environmental factors. Thus, a broad understanding of genetic background is needed for early diagnosis of AD.

Objective

Identification of candidate functional genetic variants associated with early-onset AD in Koreans.

Methods

Whole-exome sequencing (WES) was performed in three families. Sanger sequencing was used to validate detected variants in 112 AD patients and 61 controls.

Results

Functional variants were filtered by WES, and then variants related to allergic immune diseases were selected through a literature search. Two candidate non-synon

SUBMITTER: Heo WI 

PROVIDER: S-EPMC5929943 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature