An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation.

ABSTRACT:

Scope

The primary disorder underlying metabolic syndrome is insulin resistance due to excess body weight and abdominal visceral fat accumulation. In this study, it is asked if dietary intake of an ethanolic extract from Russian tarragon (Artemisia dracunculus L., termed PMI5011), shown to improve glucose utilization by enhancing insulin signaling in skeletal muscle, could prevent obesity-induced insulin resistance, skeletal muscle metabolic inflexibility, and ectopic lipid accumulation in the skeletal muscle and liver.

Methods and results

Male wild-type mice are fed a high-fat diet alone or supplemented with PMI5011 (1% w/w) over 3 months. Dietary intake of PMI5011 improved fatty acid oxidation and metabolic flexibility in the skeletal muscle, reduced insulin levels, and enh

SUBMITTER: Yu Y 

PROVIDER: S-EPMC5929974 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature