Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis.

ABSTRACT:

Objective

Nonclassical monocytes (NCM) function to maintain vascular homeostasis by crawling or patrolling along the vessel wall. This subset of monocytes responds to viruses, tumor cells, and other pathogens to aid in protection of the host. In this study, we wished to determine how early atherogenesis impacts NCM patrolling in the vasculature.

Approach and results

To study the role of NCM in early atherogenesis, we quantified the patrolling behaviors of NCM in ApoE^-/- (apolipoprotein E) and C57BL/6J mice fed a Western diet. Using intravital imaging, we found that NCM from Western diet-fed mice display a 4-fold increase in patrolling activity within large peripheral blood vessels. Both human and mouse NCM preferentially engulfed OxLDL (oxidized low-density lipopr

SUBMITTER: Marcovecchio PM 

PROVIDER: S-EPMC5930003 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature