Skeletal muscle ceramides and daily fat oxidation in obesity and diabetes.

ABSTRACT: BACKGROUND/OBJECTIVES:Ectopic accumulation of lipids in skeletal muscle and the formation of deleterious lipid intermediates is thought to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Similarly, impaired fat oxidation (metabolic inflexibility) are predictors of weight gain and the development of T2DM; however, no study has investigated the relation between muscle ceramide accumulation and 24-hour macronutrient oxidation. The purpose of this study was to retrospectively explore the relationships between whole body fat oxidation and skeletal muscle ceramide accumulation in obese non-diabetic individuals (ND) and in people with obesity and T2DM. METHODS:Daily substrate oxidation was measured in a respiratory chamber and skeletal muscle ceramides wer

SUBMITTER: Broskey NT 

PROVIDER: S-EPMC5930033 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature