Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits.

ABSTRACT:

Background

Apamin-sensitive small conductance calcium-activated K current (I_KAS) is up-regulated during ventricular pacing and masks short-term cardiac memory (CM).

Objective

The purpose of this study was to determine the role of I_KAS in long-term CM.

Methods

CM was created with 3-5 weeks of ventricular pacing and defined by a flat or inverted T wave off pacing. Epicardial optical mapping was performed in both paced and normal ventricles. Action potential duration (APD₈₀) was determined during right atrial pacing. Ventricular stability was tested before and after I_KAS blockade. Four paced hearts and 4 normal hearts were used for western blotting and histology.

Results

There were no significant differences in either ec

SUBMITTER: Yin D 

PROVIDER: S-EPMC5930041 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature