A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial.

ABSTRACT:

Background

Whole-grain intake is associated with lower risk of type 2 diabetes but the mechanisms are unclear.

Purpose

We tested the hypothesis that a WG diet reduces insulin resistance and improves glucose use in individuals at risk for type 2 diabetes compared with an isocaloric-matched refined-grain diet.

Methods

A double-blind, randomized, controlled, crossover trial of 14 moderately obese adults (Age, 38 ± 2 y; BMI, 34.0 ± 1.1 kg/m²). Insulin resistance and glucose metabolism was assessed using an oral glucose tolerance test combined with isotopic tracers of [6,6-²H₂]-glucose and [U-¹³C]-glucose, and indirect calorimetry. Peripheral and hepatic insulin resistance was assessed as 1/(rate of disposal/insulin), and endogen

SUBMITTER: Malin SK 

PROVIDER: S-EPMC5930046 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature