Early detection of hepatocellular carcinoma using autoantibody profiles from a panel of tumor-associated antigens.

ABSTRACT:

Background

Multiple antigen miniarrays used for detecting autoantibodies to tumor-associated antigens (TAAs) can be a useful approach for cancer detection and diagnosis. We here address a very specific question: might there be autoimmune responses to TAAs which precede clinical detection of hepatocellular carcinoma (HCC) in HBV and HCV chronic liver disease patients under continuous medical surveillance, and if so, could these anti-TAAs be added to the armamentarium of diagnostic tests?

Methods

We here examine the utility of a panel of 12 TAAs for the diagnosis of hepatocellular carcinoma (HCC). We derived a predictive rule for the presence of HCC based on the panel, from a cohort comprising 160 HCC patients and 90 normals. We then applied this rule to sequential anti-TAA da

SUBMITTER: Koziol JA 

PROVIDER: S-EPMC5930126 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature