Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis: Results from a clinical trial cohort.

ABSTRACT:

Background

Limited prospective information exists regarding spectral-domain optical coherence tomography (SD-OCT) in secondary progressive multiple sclerosis (SPMS).

Objective

Document cross-sectional and longitudinal retinal nerve fiber layer (RNFL) and macular ganglion cell plus inner plexiform layer (GCIPL) features of an SPMS clinical trial cohort.

Methods

Prospective, observational study using a 2-year randomized placebo-controlled SPMS trial cohort with yearly SD-OCT testing. Post hoc analysis determined influences of optic neuritis (ON), disease duration, and baseline SD-OCT on annualized atrophy rates and on correlations between OCT and brain atrophy.

Results

Mean RNFL and GCIPL values of patients ( n = 47, mean age = 59 years, mean disease duration = 3

SUBMITTER: Winges KM 

PROVIDER: S-EPMC5930161 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature